OUR RESEARCH

Lab technologies

CODEX (CO-Detection by indEXing) -- fluorescence-based highly multiplexed microscopy using the Akoya Phenocycler and a Keyence BZ-X810 microscope

TMA Grand Master (3D Histech) for high-throughput, high-precision tissue microarrays

Brightfield scanner (3D Histech) for digital TMA annotation with the Grand Master

AccuLift Yoda Laser Capture Microdissection microscope (Standard Biotools, formerly Fluidigm)

Projects

BONE MARROW MICROENVIRONMENT IN LEUKEMIA PROGRESSION

We use murine models of chronic myeloid leukemia (CML) to study how the bone marrow (BM) microenvironment changes during leukemia progression and how the BM immune system is affected by immunotherapies. We are also interested in the biology of hematopoietic and leukemic stem cells (HSCs, LSCs) and how the immune system regulates them.

Image: CML at different time points analyzed by CODEX